Coxibs and cardiovascular disease.
نویسنده
چکیده
منابع مشابه
Review of the cardiovascular safety of COXIBs compared to NSAIDS
There is no doubt that NSAIDs and COXIBS are the mainstay for managing pain and inflammation in arthritis. Overall, at therapeutically equivalent doses, both NSAIDs and COXIBs provide equivalent analgesic and anti-inflammatory efficacy. However, the gastrointestinal risk associated with NSAIDs is considerable. More recently, the cardiovascular risk associated with NSAIDs and COXIBs has become a...
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The selective COX-2 inhibitors (coxibs) were originally developed to minimise the adverse effects of conventional non-steroidal anti-inflammatory drugs (NSAIDs) while maintaining the same analgesic and anti-inflammatory properties. Many large studies confirmed the improved gastric side effect profile of coxibs compared with non-selective NSAIDs; however, reports of increased cardiovascular morb...
متن کاملCardiovascular Effects of COX-2 Inhibitors: A Review of the Literature
When cyclooxygenase-2 (COX-2) inhibitors (coxibs) came on the market, they were expected to provide a treatment alternative to nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) for patients who were at risk for gastrointestinal (GI) complications. For more than five years, coxibs have been prescribed to millions of patients for the treatment of arthritis, acute pain, Alzheimer’s diseas...
متن کاملA Growing Class of Anti-Inflammatory Drugs
For about two years, selective inhibitors of cyclooxygenase-2 have been hailed as powerful additions to the armamentarium of nonsteroidal anti-inflammatory drugs (NSAIDs). Predicted by financial analysts to become among the pharmaceutical industry's greatest-ever blockbusters, two so-called coxibs are now widely utilized clinically: rofecoxib (Vioxx, Merck) and celecoxib (Celebrex, Monsanto). T...
متن کاملThe cardiovascular pharmacology of COX-2 inhibition.
Selective inhibitors of cyclooxygenase (COX)-2, the coxibs, were developed to inhibit inflammatory prostaglandins derived from COX-2, while sparing gastroprotective prostaglandins primarily formed by COX-1. However, COX-2-derived prostaglandins mediate not only pain and inflammation but also affect vascular function, the regulation of hemostasis/ thrombosis, and blood pressure control. All coxi...
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عنوان ژورنال:
- The New England journal of medicine
دوره 351 17 شماره
صفحات -
تاریخ انتشار 2004